Automated peptide mapping and protein-topographical annotation of proteomics data
نویسندگان
چکیده
منابع مشابه
Validation of Automated Protein Annotation
Given the large amount of data stored in biological databases, the management of uncertainty and incompleteness in them is a non-trivial problem. To cope with the large amount of sequences being produced, a significant number of genes and proteins have been functionally characterized by automated tools. However, these tools have also produced a significant number of misannotations that are now ...
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MOTIVATION Assignment of putative protein functional annotation by comparative analysis using pre-defined experimental annotations is performed routinely by molecular biologists. The number and statistical significance of these assignments remains a challenge in this era of high-throughput proteomics. A combined statistical method that enables robust, automated protein annotation by reliably ex...
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Large-scale annotation of sets of proteins is a frequently occurring task in association with genome sequencing projects. Here, we present an automated platform for the functional annotation of large sets of protein sequences. Various bioinformatics tools are used to achieve a comprehensive description of protein sequences and to link these results to standard Gene Ontology descriptors for mole...
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Cell function is dependent upon the co-ordinated and dynamic formation of complex interaction networks between molecules of diverse biochemical properties. These networks, or interactomes, are comprised of macromolecular biopolymers; proteins, DNA, RNA and polysaccharides, in addition to non-polymer compounds such as small molecular metabolites. This myriad of interactions is highly regulated a...
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Introduction The availability of novel mapping systems and software in combination with or without dedicated multipolar diagnostic catheters allows for automatic high-density 3-dimensional electroanatomic mapping that enables detailed insight into atrial tachycardia mechanisms. For the accuracy of the activation map, the consistency of electrogram annotation is crucial. Depending on the system ...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2014
ISSN: 1471-2105
DOI: 10.1186/1471-2105-15-207